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Inhibition of EGFR-AKT axis results in the suppression of ovarian tumors in vitro and in preclinical mouse model.
Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies.
Principal Investigator
What beta-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism.
Quantitative proteomic analysis of oligodendrogliomas with and without 1p/19q deletion.
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Bezanilla, Francisco
One or more keywords matched the following items that are connected to
Bezanilla, Francisco
Item Type
Name
Concept
Sodium-Potassium-Exchanging ATPase
Concept
Biophysics
Concept
Electrophysiology
Concept
Hippocampus
Concept
Hydrogen-Ion Concentration
Concept
Hydrolysis
Concept
Hot Temperature
Concept
Neurophysiology
Concept
Humans
Concept
Hydrogen Bonding
Concept
Systems Integration
Concept
Kv1.1 Potassium Channel
Concept
Kv1.3 Potassium Channel
Concept
Optics and Photonics
Concept
Neurosciences
Concept
Phosphoric Monoester Hydrolases
Concept
HEK293 Cells
Concept
Hydrophobic and Hydrophilic Interactions
Concept
Gene Knockdown Techniques
Concept
History, 20th Century
Concept
KCNQ1 Potassium Channel
Concept
KCNQ2 Potassium Channel
Concept
Kv1.2 Potassium Channel
Concept
Nanotechnology
Concept
KCNQ Potassium Channels
Concept
Electrochemistry
Concept
Heart Rate
Concept
Histidine
Concept
Kinetics
Concept
Bridged Bicyclo Compounds, Heterocyclic
Concept
Computational Biology
Concept
Protein Kinase Inhibitors
Academic Article
Tracking voltage-dependent conformational changes in skeletal muscle sodium channel during activation.
Academic Article
A physical model of potassium channel activation: from energy landscape to gating kinetics.
Academic Article
Voltage sensor movements.
Academic Article
A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site.
Academic Article
Extensive editing of mRNAs for the squid delayed rectifier K+ channel regulates subunit tetramerization.
Academic Article
Perturbation analysis of the voltage-sensitive conformational changes of the Na+/glucose cotransporter.
Academic Article
A fluorometric approach to local electric field measurements in a voltage-gated ion channel.
Academic Article
RNA editing of a human potassium channel modifies its inactivation.
Academic Article
A hybrid approach to measuring electrical activity in genetically specified neurons.
Academic Article
beta-Scorpion toxin modifies gating transitions in all four voltage sensors of the sodium channel.
Academic Article
Voltage-gated ion channels.
Academic Article
Optical detection of rate-determining ion-modulated conformational changes of the ether-à-go-go K+ channel voltage sensor.
Academic Article
S4-based voltage sensors have three major conformations.
Academic Article
Fluorescence detection of the movement of single KcsA subunits reveals cooperativity.
Academic Article
The origin of subconductance levels in voltage-gated K+ channels.
Academic Article
Silicon chip-based patch-clamp electrodes integrated with PDMS microfluidics.
Academic Article
A single charged voltage sensor is capable of gating the Shaker K+ channel.
Academic Article
Coupling between the voltage-sensing and phosphatase domains of Ci-VSP.
Academic Article
Gating currents from neuronal K(V)7.4 channels: general features and correlation with the ionic conductance.
Academic Article
Analysis of the optimal channel density of the squid giant axon using a reparameterized Hodgkin-Huxley model.
Academic Article
Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 segments in the closed state of Shaker K channel.
Academic Article
Controlling the activity of a phosphatase and tensin homolog (PTEN) by membrane potential.
Academic Article
How membrane proteins sense voltage.
Academic Article
Energy landscape of the reactions governing the Na+ deeply occluded state of the Na+/K+-ATPase in the giant axon of the Humboldt squid.
Academic Article
Gating currents from Kv7 channels carrying neuronal hyperexcitability mutations in the voltage-sensing domain.
Academic Article
Tuning the voltage-sensor motion with a single residue.
Academic Article
An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations.
Academic Article
Infrared light excites cells by changing their electrical capacitance.
Academic Article
The contribution of individual subunits to the coupling of the voltage sensor to pore opening in Shaker K channels: effect of ILT mutations in heterotetramers.
Academic Article
In vivo measurement of intramolecular distances using genetically encoded reporters.
Academic Article
The dynamic relationships between the three events that release individual Na? ions from the Na?/K?-ATPase.
Academic Article
Nano-positioning system for structural analysis of functional homomeric proteins in multiple conformations.
Academic Article
Molecular mechanism for depolarization-induced modulation of Kv channel closure.
Academic Article
Intermediate state trapping of a voltage sensor.
Academic Article
The voltage sensor and the gate in ion channels.
Academic Article
Fast gating in the Shaker K+ channel and the energy landscape of activation.
Academic Article
Detection of the opening of the bundle crossing in KcsA with fluorescence lifetime spectroscopy reveals the existence of two gates for ion conduction.
Academic Article
Properties of deactivation gating currents in Shaker channels.
Academic Article
Control of a final gating charge transition by a hydrophobic residue in the S2 segment of a K+ channel voltage sensor.
Academic Article
Ouabain binding site in a functioning Na+/K+ ATPase.
Academic Article
IKs channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits.
Academic Article
Thermal mechanisms of millimeter wave stimulation of excitable cells.
Academic Article
Probing a-3(10) transitions in a voltage-sensing S4 helix.
Academic Article
Real-time imaging of electrical signals with an infrared FDA-approved dye.
Academic Article
A structural rearrangement of the Na+/K+-ATPase traps ouabain within the external ion permeation pathway.
Academic Article
Native chemical ligation at Asx-Cys, Glx-Cys: chemical synthesis and high-resolution X-ray structure of ShK toxin by racemic protein crystallography.
Academic Article
Molecular bases for the asynchronous activation of sodium and potassium channels required for nerve impulse generation.
Academic Article
Sensing charges of the Ciona intestinalis voltage-sensing phosphatase.
Academic Article
The gating charge should not be estimated by fitting a two-state model to a Q-V curve.
Academic Article
S3-S4 linker length modulates the relaxed state of a voltage-gated potassium channel.
Academic Article
Moving gating charges through the gating pore in a Kv channel voltage sensor.
Academic Article
Mechanism of potassium ion uptake by the Na(+)/K(+)-ATPase.
Academic Article
Functional Site-Directed Fluorometry.
Academic Article
Resting state of the human proton channel dimer in a lipid bilayer.
Academic Article
Kv3.1 uses a timely resurgent K(+) current to secure action potential repolarization.
Academic Article
Heterogeneous silicon mesostructures for lipid-supported bioelectric interfaces.
Academic Article
Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET.
Academic Article
Mechanism of functional interaction between potassium channel Kv1.3 and sodium channel NavBeta1 subunit.
Academic Article
Development of a PET radioligand for potassium channels to image CNS demyelination.
Academic Article
Biophysical Characterization of Genetically Encoded Voltage Sensor ASAP1: Dynamic Range Improvement.
Academic Article
Charge translocation by the Na/K pump.
Academic Article
LRET Determination of Molecular Distances during pH Gating of the Mammalian Inward Rectifier Kir1.1b.
Academic Article
Gating currents.
Academic Article
Influences: The Cell Physiology Laboratory in Montemar, Chile.
Academic Article
Cholesterol Functionalization of Gold Nanoparticles Enhances Photoactivation of Neural Activity.
Academic Article
Methodological improvements for fluorescence recordings in Xenopus laevis oocytes.
Academic Article
Continuum Gating Current Models Computed with Consistent Interactions.
Academic Article
Nongenetic optical neuromodulation with silicon-based materials.
Academic Article
An atlas of nano-enabled neural interfaces.
Academic Article
Metal Bridge in S4 Segment Supports Helix Transition in Shaker Channel.
Academic Article
Loss-of-function BK channel mutation causes impaired mitochondria and progressive cerebellar ataxia.
Academic Article
Transient Electrical Currents Mediated by the Na+/K+-ATPase: A Tour from Basic Biophysics to Human Diseases.
Academic Article
Tracking the movement of discrete gating charges in a voltage-gated potassium channel.
Academic Article
Noncanonical electromechanical coupling paths in cardiac hERG potassium channel.
Grant
ISS ChronosBH Fluorescence Lifetime Spectrometer
Grant
Surface Plasmon-coupled Fluorescence Microscope to Study Ion Channel Dynamics
Grant
ELECTROPHYSIOLOGICAL STUDIES OF VOLTAGE GATED CHANNELS
Grant
Charge translocation by the sodium-potassium pump in the giant axon of the Humbol
Grant
Cell-targeted Gold Nanoparticles for Photo-excitation fo Retinal Ganglion Cells
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